What science understands about why Type 1 diabetes happens: autoimmunity, genetics, environmental and viral triggers, and the gaps researchers are still working to close.
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New research is uncovering which genes inflammation activates inside the cells that make insulin. Understanding this connection could open doors to better understanding how Type 1 diabetes develops.
Type 1 diabetes develops when the immune system attacks insulin-producing cells in the pancreas. Scientists are now recreating this process in the lab to better understand what triggers the disease.
New research reveals that a key part of your immune system acts as a sensor for nutritional status and metabolic health. Understanding this connection may help explain links between diet, metabolism, and Type 1 diabetes.
Type 1 diabetes doesn't start the day you feel sick. Scientists are uncovering the genetic, immune, and environmental factors that set the stage for the disease years in advance.
Researchers used CRISPR gene editing to modify insulin-producing cells so they could evade the immune system. Early results from one patient suggest the approach may be worth pursuing further.
New research reveals that when beta cells are under stress, they undergo chemical changes that can make them look foreign to the immune system. Understanding these changes could open new doors for preventing or slowing Type 1 diabetes.
Glutamate and glutamine help pancreatic cells make insulin and stay healthy. New research suggests problems with these amino acids may contribute to Type 1 diabetes development.
A small clinical trial at University of Chicago is testing an islet cell transplant procedure for people with Type 1 diabetes. Early reports from three patients show varied results, with some reducing insulin use.
Research shows that SARS-CoV-2 can affect the pancreas and other organs involved in blood sugar control. Understanding these connections may help us better recognize and manage diabetes in people who have had COVID-19.
Researchers found that people with Type 1 diabetes have elevated levels of proteins in their blood associated with neurodegeneration. These findings may help explain the increased risk of dementia seen in the Type 1 diabetes community.
Researchers are studying additional medications that could help prevent kidney damage in people with Type 1 diabetes. These therapies target different causes of kidney injury and offer hope for better protection against a serious complication.
Researchers developed a gel containing graphene oxide and an oxygen-releasing compound that could help protect pancreatic beta cells after transplantation. Early lab tests show promise for future Type 1 diabetes therapies.
A new study of teenagers with Type 1 diabetes found that muscle mass, not fatty liver, was linked to early signs of blood vessel changes. Here's what that means for cardiovascular risk.
Researchers in Tunisia found distinct antibody patterns linked to two potential environmental factors in newly diagnosed Type 1 diabetes patients. The findings add to growing evidence about what might trigger the autoimmune attack on insulin-producing cells.
Despite advances in diabetes care, people with Type 1 diabetes face a significantly higher risk of cardiovascular disease. Researchers and organizations are working to develop better therapies to address this gap.
Researchers found that certain immune cells called monocytes behave differently in newly diagnosed children with Type 1 diabetes. These differences may help predict how well children respond to insulin treatment.
Research in rats suggests that exposure to parasitic antigens alongside diabetes-triggering conditions can intensify inflammation and tissue damage. Understanding this link may help scientists identify new factors that influence disease progression.
Researchers found that modulating prostaglandin E2 signaling—a molecule involved in inflammation and cell health—protected insulin-producing beta cells in a laboratory model of aggressive autoimmune attack. The findings suggest a potential new avenue for protecting the body's own insulin factories.
A study of nearly 370 children and teens found that DKA cases did peak in winter months, but the pattern may not be as simple as the season itself. Other factors—like infections and access to care—may play a bigger role.
New research identifies molecular markers that may help predict which children with diabetic ketoacidosis face greater risk of kidney damage.
Type 1 diabetes happens when the immune system attacks insulin-producing cells in the pancreas. Scientists have made significant progress understanding why this occurs, though many questions remain.
A new study reveals that some people clinically diagnosed with Type 1 diabetes may actually have a different form of the disease. Genetic testing could help identify who needs different care.
Researchers used machine learning to narrow down thousands of potential culprits—hybrid insulin peptides—that may trigger the immune attack on pancreatic cells. This work could eventually help predict who will develop Type 1 diabetes.
New research challenges the traditional view of Type 1 diabetes as purely an immune attack. Evidence suggests that stressed beta cells themselves may play an active role in triggering autoimmunity.
Researchers found that a naturally occurring molecule is more active during periods when Type 1 diabetes improves on its own. New studies suggest it may help the immune system calm down and support insulin-producing cells.
New research suggests that changes in gut bacteria may play a role in Type 1 diabetes development, not just as a result of the disease. Scientists are working to understand how the microbiota, immune system, and pancreas communicate.
Researchers have long suspected that viral infections play a role in Type 1 diabetes onset. New evidence is clarifying which viruses matter most and how they might contribute to the disease.
New research suggests physical activity could play a role in reducing the autoimmune attack on insulin-producing cells. While early findings are promising, scientists say much more work is needed to understand how exercise influences Type 1 diabetes at the immune level.
Scientists are learning that regulatory T cells—immune cells designed to prevent autoimmune disease—aren't all alike. Understanding how they fail in Type 1 diabetes could open new doors for treatment.
Researchers have developed a computational method that analyzes gut bacteria patterns to detect early warning signs of Type 1 diabetes. The approach could eventually help identify people at risk before the disease emerges.
Researchers using advanced genetic analysis found two proteins that show promise as early warning signs of Type 1 diabetes. These findings could eventually help doctors identify the disease sooner, though more testing is needed.
A small clinical trial found that the BCG vaccine may help improve long-term blood sugar control in children with Type 1 diabetes. Researchers are exploring whether this vaccine can modulate the immune system in ways that benefit the pancreas.
Scientists are uncovering why some viral infections appear linked to Type 1 diabetes onset. A new study shows how peptides from viruses like chikungunya and dengue may disrupt the normal signals that tell pancreatic cells to make insulin.
Research shows that children with Type 1 diabetes have differences in their gut bacteria compared to healthy peers. Scientists are exploring whether these microbial changes play a role in the disease and could inform new prevention strategies.
New research in adults with Type 1 diabetes finds that keeping glucose levels in a very narrow, near-normal range is linked to lower rates of diabetic retinopathy and healthier blood vessel patterns in the eye.
Scientists are discovering that the immune system doesn't just attack our own proteins—it attacks modified versions of them. Understanding these changes could reshape how we think about autoimmune disease.
New research reveals the metabolic chaos that unfolds when Type 1 diabetes first develops. A class of diabetes drugs called GLP-1 receptor agonists may help preserve insulin-producing cells and reduce insulin needs—at least while taking them.
A growing body of evidence suggests that rotavirus infection in early childhood may increase the risk of developing Type 1 diabetes. Understanding this connection could help inform prevention strategies for families.
Scientists have examined pancreatic tissue from 88 donors to map the immune changes that happen in the earliest stages of type 1 diabetes. The findings point to specific immune cells that may drive the disease before beta cells are extensively damaged.
Researchers analyzed two decades of data on early-onset chronic kidney disease to understand how the condition affects young people worldwide and predict future trends.
Researchers have identified immune cell signatures in the blood that could improve how doctors identify people at risk for Type 1 diabetes. This advance could help refine who needs closer monitoring and earlier intervention.
Researchers have identified a shared molecular marker in both Type 1 diabetes and Sjögren's syndrome, suggesting these two autoimmune conditions may operate through similar immune mechanisms. This discovery could eventually help scientists better understand what triggers autoimmune disease.
A large genetic study shows that how type 1 diabetes develops depends partly on which autoantibody appears first—and different genetic factors may be at play depending on that path.
A new study from Croatia reveals that specific genetic markers called HLA class II alleles strongly influence who develops Type 1 diabetes and whether they'll also develop conditions like thyroid disease or celiac disease.
A new study shows that two common blood sugar measurements used in Type 1 diabetes trials don't always tell the same story. Here's what that means for research and treatment tracking.
Scientists have identified a potential explanation for why people with Type 1 diabetes face a higher risk of developing multiple sclerosis: the immune system may be attacking a protein found in nerve insulation.
Scientists have identified a biological pathway that may explain why some children with Type 1 diabetes experience cognitive challenges. This discovery could open doors to new treatment approaches.
Research shows that people with Type 1 diabetes are more likely to develop celiac disease, and the reason lies in shared genetic risk factors. Understanding this connection may help doctors identify and monitor patients who face both risks.
Researchers are uncovering how pancreatic beta cells inadvertently create disease-triggering protein fragments through a natural recycling process. Understanding this mechanism could open new paths to prevention and treatment.
New research suggests that the earlier a child is diagnosed with Type 1 diabetes, the more likely they may develop celiac disease. Understanding this connection could help doctors know who to screen.
Researchers in Latvia tested siblings of children with Type 1 diabetes to catch the disease early, before symptoms appear. About one-third tested positive for warning signs that could allow for early intervention.
Scientists are uncovering how mutations in a gene called IFIH1 affect the immune system's ability to detect viruses—and may influence who develops Type 1 diabetes. Understanding this connection could open new doors for targeted treatments.
Researchers identified two RNA markers that distinguish which patients respond to a three-drug combination therapy in latent autoimmune diabetes. The findings could pave the way for personalized treatment strategies in this understudied diabetes type.
A genetic study finds evidence that both Type 1 and Type 2 diabetes raise the risk of pyelonephritis, a serious infection of the kidneys. The connection appears to be direct, not simply caused by weight or blood sugar changes.
A new review examines how vitamin A influences pancreatic beta cells and the immune system in Type 1 diabetes. The findings suggest vitamin A plays a complex role that could inform future nutritional approaches.
Scientists used genetic analysis to identify three genes involved in lactate processing that may influence Type 1 diabetes risk. The findings could help researchers better understand how metabolism and immunity connect in the disease.
New research in diabetic rats suggests that specific probiotics may help protect testicular function by affecting how genes are regulated at the molecular level. The findings point to a potential link between gut microbiota and reproductive complications in Type 1 diabetes.
Scientists are uncovering how extracellular vesicles—microscopic packages that cells use to communicate—may play a role in Type 1 diabetes development. Understanding these messengers could open new doors for diagnosis and treatment.
A new study shows that children identified through genetic screening and followed closely before diagnosis experience milder disease onset and better outcomes in their first year.
Type 1 diabetes develops gradually over years before symptoms appear, creating a window of opportunity for early intervention. Teplizumab (Tzield) is the first FDA-approved therapy designed to delay this progression in children and teens.
Scientists have identified autoantibodies—proteins in the blood—as reliable markers that someone may develop Type 1 diabetes. A major review examined decades of research to understand how well these tests work across different populations.
Researchers discovered that inflammation in the pancreas can chemically alter insulin molecules, creating modified versions that may be recognized differently by the immune system. Understanding these changes could help explain how autoimmunity develops in Type 1 diabetes.
New research suggests that oxidative damage to insulin molecules inside pancreatic beta cells could be a key driver of autoimmunity in Type 1 diabetes. Understanding this process may open new avenues for detection and intervention.
New research reveals that cellular aging processes play a role in both the onset and progression of Type 1 diabetes. Understanding this connection could open doors to new ways to prevent and treat the disease.
Scientists used genetic analysis to explore why people with inflammatory bowel disease often develop related conditions. The findings offer clues about how genes and environment shape disease connections.
A new study finds that specific nutrients in infants' diets are linked to intestinal permeability and inflammation markers associated with Type 1 diabetes risk. The findings suggest that early nutrition could play a role in how the developing immune system responds.
Scientists are discovering that mitochondrial dysfunction plays a key role in Type 1 diabetes and its complications. New research suggests some diabetes medications might help repair this cellular damage, though much work remains.
A new UK study reveals what doctors and nurses think about screening and monitoring children with early-stage Type 1 diabetes—and what barriers they face in putting these strategies into practice.
New research in mice suggests that intermittent fasting helps preserve heart function in type 1 diabetes by changing gut bacteria and producing a protective metabolite. While early, these findings point to a new way to think about managing diabetes-related heart complications.
A rat study found that both moderate and intense exercise reversed harmful changes in microRNA expression linked to Type 1 diabetes. The findings suggest exercise may work at a cellular level to improve blood sugar control.
A survey of 410 patients in China reveals gaps in understanding diabetic nephropathy, a serious complication that affects the kidneys. Knowledge, attitudes, and everyday practices all play a role in whether people take steps to protect their kidney health.
A small clinical trial found that taking mealtime insulin 15 minutes before eating led to better blood sugar control and increased blood flow to the heart compared to injecting insulin after meals began.
Researchers have identified a marker that appears on harmful immune cells in Type 1 diabetes, and early evidence suggests targeting these cells could prevent the disease without suppressing the entire immune system.
New research reveals that chemical modifications to DNA and related molecules can alter how blood-forming cells develop, potentially driving the immune attack on insulin-producing cells. Understanding these epigenetic changes may open new avenues for prevention and treatment.
A major study validates that changes in gene activity shortly after diagnosis are linked to how quickly insulin production declines. These findings could eventually help doctors understand why the disease progresses differently from person to person.
Researchers are finding that viral, bacterial, and other infections can damage hormone-producing glands through multiple pathways. Understanding these connections could help doctors recognize and prevent long-term complications.
A new systematic review and meta-analysis examines whether respiratory infections in pregnancy and early childhood are connected to the development of islet autoimmunity and type 1 diabetes. Here's what the evidence shows so far.
Researchers analyzed decades of health data to understand how inherited genes affect kidney function in people with Type 1 diabetes. The findings could help identify who may need closer monitoring.
Early research in mice and cell cultures suggests that 4-methylumbelliferone may help preserve the pancreatic beta cells that are destroyed in Type 1 diabetes. Scientists are still working to understand how it works and whether it could eventually help people.
Scientists are discovering that measuring inflammatory signals in the blood could provide a more complete picture of Type 1 diabetes development than antibody tests alone. This new understanding may eventually lead to better ways to identify who is at risk—and when to intervene.
Researchers are exploring whether specially designed bacteria that produce specific immune-regulating compounds could delay or prevent type 1 diabetes in at-risk individuals. Early laboratory studies in mice show promise for this novel approach.
New research reveals that Coxsackievirus B uses a clever trick to hide from one part of the immune system while triggering another. Understanding this imbalance could help researchers design better ways to prevent the virus from triggering autoimmunity.
Scientists have discovered that when immune cells die in unusual ways, they can fuel the inflammation that leads to Type 1 diabetes. Understanding these cell death pathways could open doors to new treatments.
Researchers have identified an enzyme called nardilysin as potentially playing a role in immune system dysregulation across multiple autoimmune conditions, including Type 1 diabetes. Understanding this enzyme could open new avenues for research into how these diseases develop.
New research identifies a molecular mechanism that regulates how a virus linked to Type 1 diabetes replicates in insulin-producing cells. Understanding this process could eventually point to new research directions.
Researchers have identified type 5 diabetes as a separate form of the disease, distinct from type 1 and type 2, that primarily affects young people in low- and middle-income countries with a history of malnutrition. Understanding this condition could help prevent misdiagnosis and guide more appropriate treatment appro…
Researchers found that measuring a protein called cubilin in urine could help identify which people with Type 1 diabetes are at risk for diabetic nephropathy, a serious kidney complication.
Researchers used an advanced imaging technique to detect subtle changes in blood flow and fat buildup in the livers of animals with type 1 diabetes, suggesting a way to catch liver complications earlier.
New research identifies a link between fear of hypoglycemia and problematic eating patterns in adults with type 1 diabetes, pointing to a potential target for clinical support.
New research is uncovering the genetic factors that influence how Type 1 diabetes affects the kidneys. Understanding these genetic links may help predict who is at higher risk for kidney complications.
Pluripotent stem cell therapies promise to treat Type 1 diabetes and other diseases, but the immune system often rejects them. Researchers are developing genetic modifications to help these therapies evade rejection.
A Phase 3 clinical trial called DIAGNODE-3 is testing whether Diamyd can slow or delay Type 1 diabetes in people who are genetically at risk and show early signs of the disease. Agreement with the FDA on how to measure success could help bring results faster.
Researchers found that syntaxin-4, a protein essential for insulin release, shows different patterns in people with Type 1 diabetes compared to those without it. Understanding these changes may help explain why insulin production declines over time.
IgG4-related disease is an uncommon systemic disorder that can damage the pituitary gland and cause hormone deficiencies. Doctors are increasingly recognizing this condition as an important diagnosis to consider.
A new clinical review examines how SGLT inhibitors—medications originally developed for Type 2 diabetes—may help some adults with Type 1 diabetes protect their hearts and kidneys. But they require careful monitoring and specific precautions to use safely.
Researchers are investigating genistein, a compound found in soy, as a potential way to help regulate immune system activity in autoimmune diseases like Type 1 diabetes. Early laboratory findings are promising, but human studies are still limited.
New research reveals that immune cells release tiny particles containing molecules that could interfere with insulin production and metabolism in Type 1 diabetes. Understanding these communication pathways may eventually help scientists find new ways to protect the pancreas.
A new study reveals that overweight and obesity are common among young people with type 1 diabetes, and higher insulin needs may be a clue to what's happening.
Type 1 diabetes requires both inherited genetic risk and exposure to environmental triggers. New research approaches are helping scientists understand how these pieces fit together and identify who is at highest risk.
A large analysis of safety reports found that certain immunotherapy combinations used to treat liver cancer were associated with a heightened signal for fulminant Type 1 diabetes, alongside other serious immune-related side effects. Understanding these risks helps doctors and patients make informed treatment decisions.
A large study of Spanish adults with Type 1 diabetes found that nearly one in three screened positive for disordered eating behaviors. Women, those with higher blood sugar levels, and people reporting poorer health faced the greatest risk.
New research shows that automated insulin delivery systems reduce serious complications compared to traditional insulin injections. Understanding the real-world impact—and the costs involved—matters for patients, families, and healthcare systems.
Researchers have developed a method to detect rapid changes in blood proteins that signal the early stages of type 1 diabetes, offering hope for interventions before symptoms appear. The approach uses tiny blood samples collected frequently at home.
New research suggests that the HLA-DRB1*04:05 genetic variant, which increases Type 1 diabetes risk, is also associated with how well immune checkpoint inhibitors work in advanced cancer patients. The finding raises questions about the connection between autoimmune risk and cancer treatment response.
New research in rats suggests that Dendrobium huoshanense, a traditional plant remedy, changes the composition of gut microbiota in ways that might help explain its blood sugar-lowering effects.
Researchers are studying a new framework called Stage 0 to identify people who may be at risk for Type 1 diabetes before their immune system begins attacking the pancreas. Early detection could open doors to prevention strategies.
Researchers are working to identify genetic variations that might explain why some people with Type 1 diabetes experience eye and kidney damage while others don't. A new study replicates previous findings to narrow down the most promising leads.
A new study reveals that aortic stenosis and diastolic dysfunction—two conditions that often occur together in heart failure—may share common genetic drivers. Understanding these connections could help doctors identify at-risk patients earlier.
Researchers engineered specially designed nanoparticles that can precisely target pancreatic beta cells, a critical step toward therapies that might protect or restore insulin production in Type 1 diabetes.
Researchers are gaining new insights into how pancreatic beta cells function—and malfunction—across different forms of diabetes. Understanding these cells is key to understanding why diabetes develops in the first place.
A new study reveals that children with newly diagnosed Type 1 diabetes lose a critical defense against low blood sugar almost immediately. Understanding this loss may help prevent dangerous hypoglycemic episodes.
A new study reveals that parental anxiety and distress—especially around managing a teenager's diabetes care—are connected to how well children keep their blood sugar in check.
Scientists are improving tests that predict Type 1 diabetes risk by considering genetic variation across different populations. Better tools could help identify at-risk individuals worldwide, not just in European ancestry groups.
When people with Type 1 diabetes receive a pancreas and kidney transplant, kidney stones can develop in the new kidney. A recent case shows how specialized surgical planning can successfully remove even large, complex stones.
A new study from Northeast India reveals how many young people diagnosed with diabetes may actually have a slower-progressing autoimmune form called LADA, often mistaken for type 2 diabetes. Early detection through antibody testing could lead to better care.
Scientists have identified a set of genes connected to gut bacteria and metabolites that may play a role in diabetic retinopathy, a serious eye complication. The findings could eventually help researchers understand how the gut influences diabetes complications.
Researchers have discovered specific T-cell receptors linked to type 1 diabetes and pinpointed the insulin-based targets these immune cells recognize. This breakthrough could help scientists understand how autoimmunity develops and identify people at risk before symptoms appear.
Doctors reported an unusual case where extreme blood sugar fluctuations may have triggered a serious brain condition, even without the usual warning signs. The discovery highlights a hidden risk that deserves more attention.
Scientists are using artificial intelligence to identify which pancreatic cells stop working properly in type 2 diabetes, a discovery that could help researchers understand disease progression and develop better treatments.
A case report documents a family in which multiple siblings developed Type 1 diabetes after recovering from COVID-19, raising questions about viral infections as potential environmental triggers in people with genetic susceptibility.
Researchers are investigating why some people with Type 1 diabetes avoid heart disease despite having risk factors. But experts say the study needs clarification on who qualifies as 'resilient' and how findings will hold up.
Researchers discovered that children with type 1 diabetes were less likely to have been infected with a common parasite than healthy children, raising questions about whether parasites might influence autoimmune disease risk.
A new study of adults with Type 1 diabetes finds that higher intake of ultra-processed foods is linked to unhealthy cholesterol patterns and changes in gut bacteria. Understanding these connections may help inform dietary choices.
New research reveals that pancreatic alpha cells share antiviral defenses similar to bats—and a key protective gene called ISG15 may explain why beta cells are more vulnerable to diabetogenic viruses.
A large study tracking people with Type 1 diabetes for over a decade found that preserving your own insulin production—measured by C-peptide—is linked to lower risk of serious complications.
Scientists discovered that a protein called Dyrk1a plays a role in heart damage caused by Type 1 diabetes. Early lab studies suggest blocking this protein might protect the heart from a serious complication called diabetic cardiomyopathy.
A study tracking pediatric diabetes cases before and after the pandemic found fluctuating diagnosis rates, with a notable spike in 2020. Researchers are still working to understand why.
Scientists studying type 1 diabetes in mice found that removing a specific protein called Adam17 slowed kidney damage, even when blood sugar remained high. This discovery could open new avenues for protecting kidney function in people with diabetes.
A new study finds that people with Type 1 diabetes show differences in how their brain cortex is folded, and these changes appear linked to both white matter damage and thinking problems. The findings suggest brain structure may help explain why some people with Type 1 diabetes experience cognitive decline.
Researchers tracked nearly 20,000 Danish newborns and found no link between vitamin D levels in infancy and later development of Type 1 diabetes or eight other autoimmune conditions. The finding challenges the idea that early vitamin D exposure shapes autoimmune disease risk.
A large international study found that children and parents participating in diabetes research stay satisfied and committed—and certain factors make the experience more meaningful for families.
Scientists discovered that regulatory immune cells can be trained to recognize and calm down against neoantigens—unusual proteins created when insulin-producing cells are under stress. This finding may open new paths for preventing Type 1 diabetes.
Researchers have identified distinct metabolic patterns in two forms of autoimmune diabetes, with tryptophan metabolism emerging as a key difference. These findings may help explain why LADA and Type 1 diabetes develop differently in the body.
New research reveals that the composition and health of our gut microbiome—the trillions of bacteria living in our digestive system—appears connected to Type 1 diabetes risk. Understanding these links may open doors to new prevention strategies.
A new laboratory study shows that iscalimab, an antibody designed to dampen immune responses, works well against B cells but falls short against the T cells that drive Type 1 diabetes.
A large genetic study has identified new biological pathways linked to diabetic peripheral neuropathy, particularly involving how the body produces and uses serine, an amino acid. These findings may eventually lead to new approaches for preventing or treating this common diabetes complication.
LADA is a form of diabetes that shares features with both Type 1 and Type 2, making it hard to diagnose. Researchers are studying blood markers that might help doctors spot it earlier and more accurately.
Scientists are investigating tiny cellular packages called extracellular vesicles as a possible link between Type 1 diabetes and Hashimoto's thyroiditis—two autoimmune conditions that often occur together.
A published case study shows how diabetic ketoacidosis can mask serious physical injuries. Doctors had to dig deeper to find what was really causing a patient's persistent symptoms.
New research shows that Type 1 diabetes interferes with the daily rhythms that help both sides of the heart work properly, and it does so differently for each side. Understanding this may help explain why heart disease is so common in people with Type 1 diabetes.
A new study found that newborns who later develop Type 1 diabetes have distinct patterns of genetic regulation and proteins in their cord blood, and these patterns differ depending on whether they carry high-risk or low-risk genes for the disease.
Researchers across China assessed how well different laboratories can identify islet autoantibodies—markers that appear before Type 1 diabetes develops. The findings reveal both the current state of testing and opportunities to make detection more consistent.
New research identifies the specific genes that inflammation switches on in insulin-producing cells during Type 1 diabetes. Understanding these molecular switches could reveal new targets for prevention and treatment.
New research shows that insulin resistance in Type 1 diabetes can damage multiple organs—even when blood sugar is well controlled. Understanding these connections may help prevent serious complications.
Three classes of medications have dramatically improved outcomes in Type 2 diabetes. Researchers are now investigating whether they offer similar cardiovascular and kidney benefits for people with Type 1 diabetes.
A newly published review examines how a specific type of RNA modification called m6A influences immune cells in Type 1 diabetes and other autoimmune conditions. Understanding this mechanism could open new research directions for treatment strategies.
Researchers found that a specific variant in the CTLA-4 gene appears more frequently in people with Type 1 diabetes from Iraq's Kurdish population. The discovery adds to our understanding of the genetic factors that influence diabetes risk.
A new study reveals that anesthesiologists in Canadian hospitals manage blood sugar before surgery in surprisingly different ways—and those differences may affect patient safety.
Immune checkpoint inhibitors, powerful cancer drugs, can rarely trigger Type 1 diabetes as a side effect. Doctors stress the importance of blood sugar monitoring during treatment to catch the condition early.
Scientists are learning how a critical protein called MAFA helps pancreatic beta cells mature and function properly—and what happens when it goes wrong in Type 1 diabetes.
A new review of published research reveals important similarities and differences in how diabetic foot ulcers develop and heal between people with Type 1 and Type 2 diabetes. Understanding these patterns matters for better patient care.
A recent animal study found that prolonged high blood sugar from Type 1 diabetes can trigger changes in key brain regions involved in memory and decision-making. Researchers are working to understand exactly what happens and whether these findings apply to people.
New research shows that a naturally occurring protein plays a role in maintaining a healthy intestinal lining and controlling inflammation during type 1 diabetes. Understanding this connection could open new avenues for research into gut health and diabetes.
Researchers are exploring whether radiofrequency signals could help restore the thymus's ability to prevent autoimmune attacks on insulin-producing cells. A new hypothesis suggests this fundamental immune process could be reset.
A study using specialized technology found that people with Type 1 diabetes have difficulty maintaining balance, especially when relying on vision or inner ear function. These findings could help develop better fall-prevention strategies.
Having type 2 diabetes—even if you take insulin—does not mean you will develop type 1 diabetes. These are two distinct conditions with different causes.
A new study reveals that people with Type 1 diabetes show altered levels of sphingosine-1-phosphate, a molecule that controls immune cell movement. These findings could help explain how the immune system goes awry in Type 1 diabetes.
Scientists are uncovering how islet-resident macrophages—specialized immune cells in the pancreas—act as metabolic control centers that either protect or harm insulin-producing β cells. Understanding these cells could open new doors for Type 1 and Type 2 diabetes treatment.
New research identifies a specific genetic variation in the CTLA-4 gene that appears more common in children with Type 1 diabetes. Understanding these genetic connections helps scientists learn more about why some people develop the condition.
A Polish research team tracked new Type 1 diabetes diagnoses across nearly 7,000 children and found that more than half presented with dangerous blood acid buildup at the time they were diagnosed—a trend that worsened during the COVID-19 pandemic.
A boy diagnosed with type 1 diabetes at age 4 turned out to have a rare genetic condition called Wolfram syndrome. His story shows why careful evaluation—and sometimes genetic testing—matters.
A large study reveals that children diagnosed with Type 1 diabetes at different ages show distinct differences in their gut bacteria, metabolism, and immune responses. These findings could help researchers better understand why Type 1 diabetes develops differently in different children.
Scientists are examining how two hormones produced by fat tissue—adiponectin and leptin—relate to cardiovascular risk in people with long-term Type 1 diabetes. Early findings suggest leptin may play a role, though more work is needed to understand what this means for clinical care.
A major clinical trial found that finerenone, a medication already used for kidney disease in type 2 diabetes, significantly reduces kidney damage markers in people with type 1 diabetes. Researchers say the findings could mean a new treatment option for a serious T1D complication.
A new study shows that people with Type 1 diabetes who retain some natural insulin production tend to have better blood sugar levels when using continuous glucose monitors. Understanding this connection may help explain why glucose control varies so much from person to person.
A patient with Type 1 diabetes experienced severe, unexplained low blood sugar 17 years after receiving a pancreas-kidney transplant. Doctors discovered an unexpected tumor was the culprit—and removing it solved the problem.
An international study found eight new genetic regions linked to Type 1 diabetes by including both European and Asian populations. These findings expand our understanding of the genes involved in the disease.
New research reveals how a naturally occurring change to insulin inside beta cells creates a stronger trigger for the immune attacks that drive Type 1 diabetes. Understanding this process could eventually help scientists develop better ways to prevent or delay the disease.
Researchers in India found that about 1 in 10 adolescents with Type 1 diabetes showed signs of liver disease on ultrasound. Understanding the connection could help protect young people's long-term health.
People with Type 1 diabetes face higher risks of heart disease and kidney damage than the general population. New research is bringing these often-overlooked complications into focus.
A new review reveals significant gaps in our understanding of why some people with Type 1 diabetes misuse insulin as a weight control method. Researchers call for better research tools and broader perspectives to help affected individuals.
A case study of a man with type 1 diabetes who experienced a stroke after a heart procedure highlights the cardiovascular risks that people with type 1 diabetes face—and why managing multiple health conditions together matters.
A new study from China reveals that people with Type 1 diabetes have distinctly different gut bacteria than healthy individuals. Understanding these differences could help researchers develop new ways to support diabetes management.
A study of children with celiac disease reveals how a gluten-free diet helps the body heal—and what happens when Type 1 diabetes is also present. Here's what parents and caregivers need to know.
A new study finds that the bacteria in breastmilk mature on a slower timeline for women with Type 1 diabetes compared to those without the condition. Understanding this difference may help researchers learn more about how Type 1 diabetes affects early infant health.
Traditional markers like genes and autoantibodies don't tell the whole story about who will develop Type 1 diabetes or how fast it will progress. New research explores how combining information from multiple biological systems could improve risk prediction.
A new study of 600 children in Kerala found that growth failure affects a significant portion of young people living with Type 1 diabetes, with specific factors making some children more vulnerable than others.
Researchers found that a genetic risk score can help identify which insulin-treated patients actually have Type 1 diabetes rather than a rare genetic form of diabetes called MODY, potentially saving time and resources in diagnosis.
Research is advancing two distinct strategies to change the course of Type 1 diabetes: immunotherapies that delay onset, and cell therapies that aim to restore the body's ability to make insulin. Here's what's happening in labs and clinics today.
Researchers have identified a protein called HDAC6 as a key driver of diabetic retinopathy, and removing it from blood vessel cells in the eye prevented vision damage in mice with Type 1 diabetes.
New research is revealing the genetic, immune, and environmental triggers that lead to Type 1 diabetes years before symptoms appear. Understanding these mechanisms is opening doors to earlier detection and new treatment approaches.
New research shows that blood glucose patterns shift across different phases of the menstrual cycle in women using automated insulin delivery systems. Understanding these changes could help improve diabetes management.
A medical case report shows how ketoacidosis in people with Type 1 diabetes can stem from multiple causes at once, making diagnosis and treatment more challenging than standard approaches.
A new study reveals that a protein called CD137, produced by immune cells that normally prevent autoimmune disease, functions in two distinct forms—each playing a separate role in holding back Type 1 diabetes development.
Researchers used advanced genetic analysis to understand how Coxsackievirus B—a virus suspected of triggering Type 1 diabetes—damages pancreatic islet cells. The findings challenge previous assumptions about which cells the virus targets.
Scientists are studying how specific proteins behave differently in healthy and diabetic kidneys to better understand diabetic nephropathy, a serious complication that can lead to kidney failure.
Scientists are developing a detailed approach to measure and map oxidative stress in Type 1 diabetes, with the goal of better understanding disease progression and designing more targeted treatments.
A case report shows that autoimmune type 1 diabetes increasingly presents in adults with features traditionally linked to type 2 diabetes, highlighting the importance of proper testing for accurate diagnosis.
A case report documents how cancer immunotherapy drugs can trigger Type 1 diabetes months after treatment ends, underscoring the need for long-term monitoring in patients who receive these medications.
Researchers examined whether having multiple autoimmune conditions alongside Graves' disease affects the severity of thyroid eye disease. The findings suggest the connection may be less common than expected.
Research comparing insulin pump therapy to daily injections shows some differences in how the heart muscle works, even when traditional heart tests look normal. Here's what parents and patients should know.
New research reveals that people with Down syndrome have higher rates of type 1 diabetes due to immune system differences and gut health changes. Understanding these connections could improve screening and care.
New research shows that Type 1 diabetes develops when genetic vulnerability meets environmental triggers—particularly viral infection. Understanding this interplay is key to developing prevention strategies.
A new study reveals that people with Type 1 diabetes and thyroid disease or celiac disease frequently have other autoimmune conditions that are never formally recognized or documented.
New research reveals that genetic factors—particularly immune-related genes—help explain why Type 1 diabetes occurs less often in Asian populations than in other parts of the world. Understanding these genetic patterns could improve how we identify and care for people at risk.
Researchers have developed a new method to expose human pancreatic cells to the stressors believed to trigger Type 1 diabetes, helping them understand how the disease develops at the cellular level.
A case study of a teenager with poorly controlled Type 1 diabetes reveals how chronic high blood sugar can lead to serious liver problems and metabolic complications. Here's what doctors learned—and why diabetes management matters.
Even lean people with Type 1 diabetes often develop insulin resistance, a condition that accelerates damage to the heart and kidneys. New research reveals why this happens and what it means for long-term health.
A blood cancer treatment called peginterferon-alpha can activate autoimmune diseases in susceptible people, including Type 1 diabetes. Understanding the risks and early warning signs matters for patients and their doctors.
New research mapping HLA genes in Russian populations reveals that genetic risk factors for Type 1 diabetes are unevenly distributed. Understanding these differences could help identify who is at highest risk.
A new study found that pediatric patients who received weekly telephone consultations about their diabetes had better blood sugar control and fewer complications than those who only saw their doctor at regular clinic visits.
A case report highlights how certain infections can trigger symptoms that closely mimic Type 1 diabetes, leading to misdiagnosis. Understanding these rare presentations matters for getting the right diagnosis and treatment.
A large genetic study examined seven different conditions—including Type 1 diabetes—to understand what raises the risk of a rare bile duct cancer. Here's what researchers found about the immune system's role in disease risk.
A large Danish study shows that screening siblings of children with Type 1 diabetes for specific autoantibodies—along with genetic testing—can accurately predict who will develop T1D, celiac disease, or thyroid disease years in advance.
New research identifies a specific protein that regulatory immune cells need to prevent the body from attacking insulin-producing cells. Understanding this mechanism could inform future treatments.
Research following nearly 20,000 people with newly diagnosed diabetes uncovered which factors increase the risk of developing heart failure—and found that some risks remain even when current treatment targets are met.
A century after insulin's discovery, researchers recognize that managing Type 1 diabetes requires addressing more than glucose levels alone. New evidence points to additional factors—like blood sugar swings and weight gain—that may increase heart disease risk.
New research explains the connection between celiac disease and Type 1 diabetes in children, and what families managing both conditions should know.
A new case report highlights how influenza infection can unmask type 1 diabetes in people with autoimmune thyroid disease. Here's what you should know about the connection.
New research shows that B lymphocytes play a bigger role in latent autoimmune diabetes in adults than scientists previously understood. Understanding how B cells function could eventually lead to better ways to identify and treat this slow-moving form of diabetes.
Doctors describe an unusual case where a rare inflammatory eye condition developed alongside diabetic eye damage, highlighting how different eye problems can interact and complicate treatment.
Researchers in Malawi report the first case of a specialized pain-blocking procedure helping a young woman with severe diabetic nerve damage. Here's what the case tells us—and what questions remain.
Researchers combined a common heartburn medication with an immune-modulating antibody to restore insulin production in mouse models of Type 1 diabetes. The approach addresses both the autoimmune destruction and the loss of beta-cell function that define the disease.
Researchers are using pancreas studies to understand how Type 1 diabetes actually develops, revealing that traditional ways of classifying diabetes can miss important clues about what's really happening in the body.
Researchers tracked type 1 diabetes diagnoses across Sweden from 2007 to 2023 to understand whether SARS-CoV-2 infection increases the risk of developing the condition. The findings offer important clues but not definitive answers.
A new study examined the blood proteins of people with decades of Type 1 diabetes who remained free from major complications, compared to those who developed them quickly. The findings may help explain who is at highest risk.
A new study finds that the Android Artificial Pancreas System—an affordable, open-source alternative to commercial insulin pumps—improved blood sugar control and quality of life for people with Type 1 diabetes in Brazil.
Researchers have developed a minimally invasive technique to identify and study the rare T cells responsible for beta cell destruction in Type 1 diabetes. This breakthrough could help scientists monitor disease activity and test new treatments more effectively.
New research reveals that about 1 in 10 women with gestational diabetes carry autoantibodies linked to Type 1 diabetes—a sevenfold higher rate than other pregnant women. Understanding this connection may help identify who needs closer monitoring.
A major study tracking chronic kidney disease across Asia found that Type 1 diabetes plays a significant role in kidney-related deaths in Southeast Asia. Understanding these regional differences helps researchers identify where better prevention and care are needed most.
Researchers documented a severe case of EBV reactivation leading to a rare immune condition in an adult with trisomy 21 who received teplizumab for stage 2 type 1 diabetes. While this outcome is uncommon, the case highlights the importance of monitoring for signs of serious infection after treatment.
New research shows that dendritic cells—immune cells that present antigens to other immune cells—play a central role in the breakdown of tolerance that leads to Type 1 diabetes. Understanding their function may open new doors to preventing the disease.
Doctors discovered that a woman's rheumatoid arthritis, type 1 diabetes, and severe digestive problems were all caused by a rare genetic immune condition called LRBA deficiency. Her case shows how multiple autoimmune diseases can sometimes point to a single underlying immune disorder.
A large study tracking thousands of genetically at-risk children found no consistent connection between dietary vitamins A and E and the development of islet autoimmunity or Type 1 diabetes.
A large study from Hong Kong examined whether a common cholesterol medication helps prevent heart disease in older people with type 2 diabetes. Here's what the research shows.
Researchers found that lipoprotein(a), a genetic risk factor for heart disease, changes more than previously thought in young people with Type 1 diabetes. This discovery could change how doctors assess cardiovascular risk in this population.